Enzymatic modification of 5′-capped RNA with a 4-vinylbenzyl group provides a platform for photoclick and inverse electron-demand Diels–Alder reaction† †Electronic supplementary information (ESI) available: See DOI: 10.1039/c4sc03182b Click here for additional data file.

Nanoparticle “switch-on” by tetrazine triggering† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6cc05118a Click here for additional data file. Click here for additional data file. Click here for additional data file.

This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels-Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent d...

Chromium photocatalysis: accessing structural complements to Diels–Alder adducts with electron-deficient dienophiles† †Electronic supplementary information (ESI) available: Experimental procedures, characterization data, electrochemistry data, UV/visible data, NMR spectra. See DOI: 10.1039/c6sc03303b Click here for additional data file.

Micro-flow photosynthesis of new dienophiles for inverse-electron-demand Diels–Alder reactions. Potential applications for pretargeted in vivo PET imaging† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc02933g Click here for additional data file.

Pretargeted PET imaging has emerged as an effective two-step in vivo approach that combines the superior affinity and selectivity of antibodies with the rapid pharmacokinetics and favorable dosimetry of smaller molecules radiolabeled with short-lived radionuclides. This approach can be based on the bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) reaction between tetrazines and trans-c...

Aromatic “Redox Tag”-assisted Diels–Alder reactions by electrocatalysis† †Electronic supplementary information (ESI) available: Additional figures, tables and general, experimental, theoretical and spectral information. See DOI: 10.1039/c6sc02117d Click here for additional data file.

Electrocatalysis was employed to promote Diels–Alder reactions between electronically mismatched substrates. A catalytic amount of electricity was enough to complete the overall reactions and GC-MS monitoring and CV measurements clearly illustrated the electrocatalytic nature of the reactions, which involve an EC-backward-E mechanism. The electrocatalytic Diels–Alder reactions were rationally d...

ENDOR characterization of an iron–alkene complex provides insight into a corresponding organometallic intermediate of nitrogenase† †Electronic supplementary information (ESI) available: Additional spectroscopic and crystallographic information. CCDC 1543306. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc01602f Click here for additional data file. Click here for additional data file.